Dopamine Neuron Systems In The Brain An Update Pdf Free
6704223018 Confocal imaging was done using either a Fluoview FV1000 (Olympus) or A1 (Nikon) confocal scanning microscope. J Neurosci 29:444453, doi:10.1523/JNEUROSCI.4029-08.2009, pmid:19144844. Viral expression of ChR2 in dopamine neurons. Abstract/FREE Full Text Kuepper R, Skinbjerg M, Abi-Dargham A (2012) The dopamine dysfunction in schizophrenia revisited: new insights into topography and course. Patch pipettes (48 M) were fabricated with a P80/PC puller (Sutter Instruments) from standard borosilicate glass capillaries with filament (World Precision Instruments). However, some VGLUT2 expression in PFC dopamine axons has been reported in retrograde tracing studies (Gorelova et al., 2012) and 25% of dopamine neurons projecting to the PFC coexpress VGLUT2 (Yamaguchi et al., 2011; Taylor et al., 2014). In the central nucleus (CeA), ChR2-EYFP+ dopamine neuron axons appeared most dense in the medial subnucleus, where the density of axons approximated that of the BLA (Fig. Dopamine neuron axons visualized by ChR2-EYFP fluorescence projected most densely to the striatum, moderately to the amygdala and entorhinal cortex (ERC), sparsely to prefrontal and cingulate cortices, and rarely to the hippocampus. Lateral ERC cells are involved in processing the salience of environmental nonspatial information (Knierim et al., 2014); dopamine neuron glutamatergic connections could signal salient events and gate ERC inputs to the hippocampus. Regional comparison of dopamine neuron glutamatergic connections and the density of ChR2-EYFP+ axons We systematically compared the incidence and strength glutamatergic connections across forebrain regions (Fig.
CrossRefMedlineGoogle Scholar Lscher C, Malenka RC (2011) Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling. Kusnoor2, Bianca Field1, Ariel Y. J Comp Neurol 498:581592, doi:10.1002/cne.21054, pmid:16917821. F2, Two superimposed traces normalized for peak amplitude, one from a strongly connected cell (light blue; EPSC amplitude of 197 pA) and another from a weakly connected cell (dark blue; EPSC amplitude 17 pA) show identical rise times, confirming that the responses were monosynaptic. Charting of ChR2-EYFP+ axons revealed densely aggregated dopamine neuron axons in the ERC (B3) and sparse innervation in the VS, DG, and CA1 subregions. Google Scholar Phillipson OT (1979) A Golgi study of the ventral tegmental area of Tsai and interfascicular nucleus in the rat. Our findings are consistent with this observation and further reveal that glutamatergic connections to the amygdala specifically target CeA and not BLA neurons. E, Summary of the amplitudes of recorded light-evoked EPSCs in the two amygdala nuclei. Latencies did not differ significantly between regions (one-way ANOVA; F(4,35) = 0.349; NS). Copyright 2015 the authors 0270-6474/15/3516259-13$15.00/0 .
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